Am J Cancer Res 2013;3(4):339-346

Review Article
Nuclear transcription factor Y and its roles in cellular processes related to
human disease

Luong Linh Ly, Hideki Yoshida, Masamitsu Yamaguchi

Department of Applied Biology, Insect Biomedical Research Center, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto,
606-8585, Japan

Received July 16, 2013; Accepted August 3, 2013; Epub August 14, 2013; Published August 30, 2013

Abstract: Nuclear transcription factor Y (NF-Y) is an example of a transcriptional regulation factor in eukaryotes consisting of
three different subunits, NF-YA, NF-YB and NF-YC, which are all necessary for formation of NF-Y complexes and binding to
CCAAT boxes in promoters of its target genes. Highly conserved between human and Drosophila, NF-Y regulates transcription
of various genes related to the cell cycle and various human diseases. Drosophila models have been widely used as tools for
studying genetics and developmental biology and more recently for analyzing the functions of human disease genes, including
those responsible for developmental and neurological disorders, cancer, cardiovascular disease and metabolic and storage
diseases, as well as genes required for function of the visual, auditory and immune systems. In this review, in vivo findings from
Drosophila models relevant to the roles of NF-Y in various human diseases are summarized. Recent studies have
demonstrated novel contributions of dNF-Y to apoptosis and apoptosis-induced proliferation, and in photoreceptor cell
differentiation during the development of the Drosophila compound eye. (ajcr0000217).

Keywords: Transcription factors, NF-Y, NF-YB, apoptosis, Drosophila model

Address correspondence to: Dr. Masamitsu Yamaguchi, Department of Applied Biology, Insect Biomedical Research Center,
Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan. Tel: +81 75 724 7781; Fax: +81 75 724 7799;
E-mail: myamaguc@kit.ac.jp
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American Journal of Cancer Research
ISSN: 2156-6976