Am J Cancer Res 2012;2(6):691-698
Review Article
The role of the c-Jun N-terminal Kinase signaling
pathway in skin cancer
Peter Boross, Jeanette H W Leusen
Jennifer Y Zhang, Maria Angelica Selim
Department of Dermatology and Pathology, Duke University, Durham, NC, USA; Department of Pathology and
Dermatology, Duke University, Durham, NC, USA
Received October 19, 2012; Accepted November 5, 2012; Epub November 20, 2012; Published November 30, 2012
Abstract: The c-Jun N-terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the
mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to
regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also
cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The
current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for
cancer type-specific applications have been summarized in this review. (ajcr0000155).
Keywords: JNK, skin cancer, squamous cell carcinoma, basal cell carcinoma, cylindroma
Address all correspondence to:
Dr. Jennifer Y Zhang
Duke Hospital S., Purple zone, Room 4032
200 Trent Drive, DUMC 3135
Durham, NC 27710-0001, USA.
Phone: (919)-684-6794; Fax: (919)-684-3002
E-mail: Jennifer.zhang@duke.edu
Review Article
The role of the c-Jun N-terminal Kinase signaling
pathway in skin cancer
Peter Boross, Jeanette H W Leusen
Jennifer Y Zhang, Maria Angelica Selim
Department of Dermatology and Pathology, Duke University, Durham, NC, USA; Department of Pathology and
Dermatology, Duke University, Durham, NC, USA
Received October 19, 2012; Accepted November 5, 2012; Epub November 20, 2012; Published November 30, 2012
Abstract: The c-Jun N-terminal Kinases (JNK), along with Erk and p38, constitute the principle members of the
mitogen-activated protein kinase (MAPK) family. JNK functions primarily through AP1 family transcription factors to
regulate a plethora of cellular processes, including cell proliferation, differentiation, survival and migration. It also
cross-talks and integrates with other signaling pathways in a cell context-specific and cell type-specific manner. The
current views of JNK function in various skin cancers and the need of developing JNK subunit-specific inhibitors for
cancer type-specific applications have been summarized in this review. (ajcr0000155).
Keywords: JNK, skin cancer, squamous cell carcinoma, basal cell carcinoma, cylindroma
Address all correspondence to:
Dr. Jennifer Y Zhang
Duke Hospital S., Purple zone, Room 4032
200 Trent Drive, DUMC 3135
Durham, NC 27710-0001, USA.
Phone: (919)-684-6794; Fax: (919)-684-3002
E-mail: Jennifer.zhang@duke.edu
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American Journal of Cancer Research
| ISSN: 2156-6976 |