Am J Cancer Res 2012;2(6):714-725
Review Article
Non-coding RNAs in DNA damage response
Yunhua Liu, Xiongbin Lu
Department of Cancer Biology, Metastasis Research Center, The University of Texas MD Anderson Cancer Center,
Houston, Texas 77030, USA
Received October 8, 2012; Accepted October 22, 2012; Epub November 20, 2012; Published November 30, 2012
Abstract: Genome-wide studies have revealed that human and other mammalian genomes are pervasively transcribed
and produce thousands of regulatory non-protein-coding RNAs (ncRNAs), including miRNAs, siRNAs, piRNAs
and long non-coding RNAs (lncRNAs). Emerging evidences suggest that these ncRNAs also play a pivotal role in genome
integrity and stability via the regulation of DNA damage response (DDR). In this review, we discuss the recent
finding on the interplay of ncRNAs with the canonical DDR signaling pathway, with a particular emphasis on miRNAs
and lncRNAs. While the expression of ncRNAs is regulated in the DDR, the DDR is also subjected to regulation by
those DNA damage-responsive ncRNAs. In addition, the roles of those Dicer- and Drosha-dependent small RNAs
produced in the vicinity of double-strand breaks sites are also described. (ajcr0000149).
Keywords: DNA damage response, ncRNAs, miRNAs, lncRNAs, crosstalk
Address all correspondence to:
Dr. Xiongbin Lu
Department of Cancer Biology, Unit-173
University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd, Houston, TX 77030, USA.
Tel: 713-745-6247
E-mail: xlu2@mdanderson.org
Review Article
Non-coding RNAs in DNA damage response
Yunhua Liu, Xiongbin Lu
Department of Cancer Biology, Metastasis Research Center, The University of Texas MD Anderson Cancer Center,
Houston, Texas 77030, USA
Received October 8, 2012; Accepted October 22, 2012; Epub November 20, 2012; Published November 30, 2012
Abstract: Genome-wide studies have revealed that human and other mammalian genomes are pervasively transcribed
and produce thousands of regulatory non-protein-coding RNAs (ncRNAs), including miRNAs, siRNAs, piRNAs
and long non-coding RNAs (lncRNAs). Emerging evidences suggest that these ncRNAs also play a pivotal role in genome
integrity and stability via the regulation of DNA damage response (DDR). In this review, we discuss the recent
finding on the interplay of ncRNAs with the canonical DDR signaling pathway, with a particular emphasis on miRNAs
and lncRNAs. While the expression of ncRNAs is regulated in the DDR, the DDR is also subjected to regulation by
those DNA damage-responsive ncRNAs. In addition, the roles of those Dicer- and Drosha-dependent small RNAs
produced in the vicinity of double-strand breaks sites are also described. (ajcr0000149).
Keywords: DNA damage response, ncRNAs, miRNAs, lncRNAs, crosstalk
Address all correspondence to:
Dr. Xiongbin Lu
Department of Cancer Biology, Unit-173
University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd, Houston, TX 77030, USA.
Tel: 713-745-6247
E-mail: xlu2@mdanderson.org
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American Journal of Cancer Research
| ISSN: 2156-6976 |