Am J Cancer Res 2011;1(6):xxx-xxx
Review Article
Dysregulation of janus kinases and signal transducers and activators of
transcription in cancer
Ana P. Costa-Pereira, Nair A. Bonito, Michael J. Seckl
Imperial College London, Faculty of Medicine, Department of Surgery and Cancer, Hammersmith Hospital Campus, Du Cane
Road, London W12 0NN, United Kingdom
Received June 5, 2011; accepted June 21, 2011; Epub June 22, 2011; Published June 30, 2011
Abstract: Despite their long recognised pivotal roles in immunological responses, Janus kinases (JAKs) and signal
transducers and activators of transcription (STATs) are now seen as important players in cancer development and progression.
Indeed, mutations in the JAKs are often found in myeloproliferative disorders (MPDs) and leukaemia, and the constitutive
phosphorylation of STATs is a common occurrence in many solid and blood cancer cell lines and primary tumour specimens.
More recently, we have also shown that JAKs likely have additional roles in promoting drug resistance in several cancer cell
types. JAKs and STATs are thus molecules that may serve as useful targets in the clinic. This review will summarise studies that
support this notion. (AJCR0000071).
Keywords: JAK, STAT, cytokines, growth factors, lung cancer, apoptosis
Full Text PDF
Address all correspondence to:
Ana P. Costa-Pereira, PhD
a.costa-pereira@imperial.ac.uk
OR
Michael J. Seckl, MD, PhD
Imperial College London, Faculty of Medicine
Department of Surgery and Cancer, Hammersmith Hospital
Du Cane Road, London W12 0NN, United Kingdom
Tel: +44 20 8383 3793
E-mail: m.seckl@imperial.ac.uk
Review Article
Dysregulation of janus kinases and signal transducers and activators of
transcription in cancer
Ana P. Costa-Pereira, Nair A. Bonito, Michael J. Seckl
Imperial College London, Faculty of Medicine, Department of Surgery and Cancer, Hammersmith Hospital Campus, Du Cane
Road, London W12 0NN, United Kingdom
Received June 5, 2011; accepted June 21, 2011; Epub June 22, 2011; Published June 30, 2011
Abstract: Despite their long recognised pivotal roles in immunological responses, Janus kinases (JAKs) and signal
transducers and activators of transcription (STATs) are now seen as important players in cancer development and progression.
Indeed, mutations in the JAKs are often found in myeloproliferative disorders (MPDs) and leukaemia, and the constitutive
phosphorylation of STATs is a common occurrence in many solid and blood cancer cell lines and primary tumour specimens.
More recently, we have also shown that JAKs likely have additional roles in promoting drug resistance in several cancer cell
types. JAKs and STATs are thus molecules that may serve as useful targets in the clinic. This review will summarise studies that
support this notion. (AJCR0000071).
Keywords: JAK, STAT, cytokines, growth factors, lung cancer, apoptosis
Full Text PDF
Address all correspondence to:
Ana P. Costa-Pereira, PhD
a.costa-pereira@imperial.ac.uk
OR
Michael J. Seckl, MD, PhD
Imperial College London, Faculty of Medicine
Department of Surgery and Cancer, Hammersmith Hospital
Du Cane Road, London W12 0NN, United Kingdom
Tel: +44 20 8383 3793
E-mail: m.seckl@imperial.ac.uk
| AJCR Copyright © 2010-present, All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711, USA |
 | |  | |  | |  | |  | |  | |  | |  |
American Journal of Cancer Research
| ISSN: 2156-6976 |