Am J Cancer Res 2011;1(2):255-264
Review Article
Oncoantigens for an immune prevention of cancer
Elisabetta Bolli, Elena Quaglino, Maddalena Arigoni, Pier-Luigi Lollini, Raffaele Calogero, Guido Forni, Federica Cavallo
Molecular Biotechnology Center, Department of Clinical and Biological Sciences, University of Turin, Torino, Italy;
Department of Hematology and Oncological Sciences, University of Bologna, Bologna, Italy.
Received December 15, 2010; accepted December 19, 2010; Epub December 20, 2010; Published January 1, 2011
Abstract: Vaccines are one of the main arms of preventive medicine. Recently a large series of experiments with cancer-prone
genetically engineered mice have shown that preventive vaccines are also extremely efficacious inhibitors of the progression of
carcinogenesis. Early vaccination affords significant and persistent protection, whereas its efficacy fades when neoplastic
lesions become more advanced. Our current attempts to use combination strategies and technological advances to make
vaccines effective in cancer prevention able to cure more advanced stages of cancer lesions are based on the temporary and
systemic Treg removal, the preparation of new bimodular plasmids for DNA vaccination and the search for fresh target
oncoantigens. (AJCR0000022).
Keywords: Oncoantigens, anti-tumor vaccination, tumor immunoprevention
Full Text PDF
Address all correspondence to:
Federica Cavallo, PhD
MBC, Via Nizza 52
10126 Torino, Italy,
Tel: +39 011 670 6457; fax: +39 011 236 5417
E-mail: federica.cavallo@unito.it
Review Article
Oncoantigens for an immune prevention of cancer
Elisabetta Bolli, Elena Quaglino, Maddalena Arigoni, Pier-Luigi Lollini, Raffaele Calogero, Guido Forni, Federica Cavallo
Molecular Biotechnology Center, Department of Clinical and Biological Sciences, University of Turin, Torino, Italy;
Department of Hematology and Oncological Sciences, University of Bologna, Bologna, Italy.
Received December 15, 2010; accepted December 19, 2010; Epub December 20, 2010; Published January 1, 2011
Abstract: Vaccines are one of the main arms of preventive medicine. Recently a large series of experiments with cancer-prone
genetically engineered mice have shown that preventive vaccines are also extremely efficacious inhibitors of the progression of
carcinogenesis. Early vaccination affords significant and persistent protection, whereas its efficacy fades when neoplastic
lesions become more advanced. Our current attempts to use combination strategies and technological advances to make
vaccines effective in cancer prevention able to cure more advanced stages of cancer lesions are based on the temporary and
systemic Treg removal, the preparation of new bimodular plasmids for DNA vaccination and the search for fresh target
oncoantigens. (AJCR0000022).
Keywords: Oncoantigens, anti-tumor vaccination, tumor immunoprevention
Full Text PDF
Address all correspondence to:
Federica Cavallo, PhD
MBC, Via Nizza 52
10126 Torino, Italy,
Tel: +39 011 670 6457; fax: +39 011 236 5417
E-mail: federica.cavallo@unito.it
| AJCR Copyright © 2010-present, All rights reserved. Published by e-Century Publishing Corporation, Madison, WI 53711, USA |
 | |  | |  | |  | |  | |  | |  | |  |
American Journal of Cancer Research
| ISSN: 2156-6976 |